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TIMI Risk Score for UA/NSTEMI

14-day risk of death, MI or urgent revascularisation in unstable angina or NSTEMI.

For healthcare professionalsCardiology scoresv1.0.0

For healthcare professionals / clinical use. Not a self-diagnosis tool.

Your measurements

Age 65 or over
3 or more CAD risk factors
Known coronary stenosis of 50% or more
Aspirin use in the past 7 days
2 or more anginal episodes in 24 hours
ST deviation of 0.5 mm or more
Positive cardiac marker

Calculated on your device. Nothing is sent to a server.

Your result will appear here

Enter your measurements, then press Calculate.

Methodology

TIMI UA/NSTEMI (Antman 2000)

1 point each for 7 criteria

Derived in the TIMI 11B trial; event rates rise with each point.

Who it is for
Adults with unstable angina or NSTEMI.
Version
1.0.0

How this calculator works

Where the formula comes from

  • Antman and colleagues (2000) derived the TIMI score in 1,957 patients with UA/NSTEMI given unfractionated heparin in the TIMI 11B trial and validated it in three cohorts from TIMI 11B and ESSENCE.[1]

The inputs

  • Seven factors score 1 point each: age 65 or over, 3 or more CAD risk factors, known coronary stenosis of 50% or more, aspirin in the past 7 days, 2 or more anginal episodes in 24 hours, ST deviation and elevated cardiac markers.[1]
  • The outcome was death, new or recurrent MI, or severe recurrent ischaemia needing urgent revascularisation within 14 days; event rates rose from 4.7% (score 0–1) to 40.9% (6–7).[1]

Where accuracy falls (published evidence)

  • The score was derived in trial populations from the 1990s, before high-sensitivity troponin and current treatment.[1]

What guidelines say

  • The 2025 ACC/AHA acute coronary syndrome guideline describes TIMI and GRACE as validated risk scores for NSTE-ACS and notes they are risk tools, not diagnostic tests.[2]

Sources

  1. Antman EM, Cohen M, Bernink PJ, et al. The TIMI risk score for unstable angina/non-ST elevation MI: a method for prognostication and therapeutic decision making. JAMA. 2000;284(7):835–842. doi:10.1001/jama.284.7.835
  2. Rao SV, O'Donoghue ML, Ruel M, et al. 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes. Circulation. 2025. doi:10.1161/CIR.0000000000001309

Compiled from the published sources above. Every statement was agreed independently by three AI research tools (Claude, ChatGPT, DeepSeek) and its source verified in PubMed or Crossref by the Hakeemly editorial team. Not reviewed by a doctor unless stated. Agreed on

Worked example: how to calculate TIMI (UA/NSTEMI)

Inputs

Age 65 or over
Yes
3 or more CAD risk factors
Yes
Known coronary stenosis of 50% or more
No
Aspirin use in the past 7 days
Yes
2 or more anginal episodes in 24 hours
No
ST deviation of 0.5 mm or more
Yes
Positive cardiac marker
No

Result

TIMI score
4 of 7

14-day event rate about 19.9% in the derivation cohort

An illustration with sample values, worked out with the same method the tool above uses.

Limitations

  • Derived before high-sensitivity troponin and modern treatment.

References

  1. Antman EM, Cohen M, Bernink PJ, et al. The TIMI risk score for unstable angina/non-ST elevation MI: a method for prognostication and therapeutic decision making. JAMA. 2000;284(7):835–842. doi:10.1001/jama.284.7.835

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